Endocrine Abstracts

Introduction: Endocrinopathies are one of the most common autoimmune adverse events (AIAEs) causing severe toxic complications during the use of checkpoint inhibitor therapy (CPI).Clinical Case: A patient with complaints of hyperpigmentation of the skin of the back in August 2022 an excisional biopsy was performed and pigmented epithelioid cell melanoma with tumor growth along the resection margin was verified. In December 2022, CT revealed metastases in...

Introduction: Hypophosphatasia is a group of inherited disorders characterized by the impaired mineralization of bones and/or teeth and low serum alkaline phosphatase (ALP) activity. It is caused by a mutation in the ALPL gene encoding the isoenzyme of ALP resulting in a loss of function. Since an early age of onset is usually associated with a more severe disease, and a late age – with a mild course of the disease, the manifestation of the disorder ranges from a life-thr...

Introduction: According to published data, pregnancy-associated osteoporosis is a rare disease, the pathophysiology of which is currently not fully explored.Сlinical case: In 2014, a 27 year-old patient B. after the first childbirth, pain appeared in the lumbosacral spine, for which a course of physical therapy was carried out with a short-term positive effect. In 2016 after the second childbirth, pains increased; according to the results of further ...

Introduction: Transnasal adenomectomy is the main treatment for various pituitary adenomas. The hypothalamic-pituitary region is the site of synthesis and secretion of several hormones that have a direct effect on sodium-water metabolism, which leads to its frequent violation with the development of central diabetes insipidus and severe transient hyponatremia, the latter of which is the second most important cause of rehospitalization in the postoperative period. Currently, th...

Introduction: Approximately 20% of patients with prolactinomas do not respond satisfactory (resistant) even to high dose dopamine agonist treatment. Worth noticing that there are no clear prognostic signs of treatment’s resistance as well as its etiology is a subject of discussion. Aim: The aim of our study was to assessabsorption and metabolism of cabergoline in patients with dopamine agonist-resistant prolactinomas.Materials...

Introduction: The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is characterized by hypotonic and euvolemic hyponatremia along with urinary hyperosmolarity, resulting from antidiuretic hormone (ADH) release in the absence of adequate stimuli.Case report: A 59-year-old woman, presented with complaints of constant thirst, general weakness, memory loss, episodes accompanied by headaches, leg cramps, increased blood pressure. From the a...

Background: Nelson syndrome is a rare complication of Cushing disease (CD), which occurs either in patients with very aggressive CD or as a result of misdiagnosis. Clinical characterization of patients with Nelson syndrome could provide important insights in management of the disorder.Methods: We analyzed medical records of patients with CD between 2015 and 2021 to identify those who developed Nelson syndrome.Results: Nine patients...

Introduction: ADH-deficiency (central diabetes insipidus, ADH-D) is a rare disease, and data on worldwide and country-specific prevalence rates are scarce. ADH-D registries could provide valuable information on epidemiology, etiological distribution, treatment requirements and potentially serve as a guide for management decisions in clinical practice.Objectives: To assess the epidemiological data on ADH-D in Russian Registry for Central Diabetes Insipidu...

Background: Acromegaly is an orphan neuroendocrine disease characterized by a variety of complications. Due to slow symptom progression acromegalic patients often are involved in growth hormone complications correction for a long time instead of search for main cause of these multiple disorders. A view on conductive hearing loss in acromegaly in literature is contradictory. The low incidence of hearing in acromegaly, compared with other complications, is presumably due to the ...

Introduction: Prolactinomas are the most common type of pituitary adenomas(40% of them), representing a significant cause of infertility and hypogonadism. About 20% of patients with prolactinomas don’t respond satisfactory(i.e. resistant) even to high dose dopamine agonist(DA) treatment(>3.5–4.5 mg/week). Worth noticing that there are no clear signs to anticipate this resistance but to stepwise increase the dose of DA. In addition, the etiology of resistance &#15...